The role of a chemokine receptor, CCR2, in sup- pressing the development of arthritis in IL-1 receptor antagonist-deficient mice
نویسندگان
چکیده
Hiroshi Fujii1), Tomohisa Baba2), Masakazu Yamagishi3), Mitsuhiro Kawano1) and Naofumi Mukaida2, *) 1)Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan 2)Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan 3)Division of Cardiology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
منابع مشابه
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells
Interleukin-17 (IL-17)-producing γδ T (γδ17) cells have been implicated in inflammatory diseases, but the underlying pathogenic mechanisms remain unclear. Here, we show that both CD4(+) and γδ17 cells are required for the development of autoimmune arthritis in IL-1 receptor antagonist (IL-1Ra)-deficient mice. Specifically, activated CD4(+) T cells direct γδ T-cell infiltration by inducing CCL2 ...
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